Our research seeks to uncover the physical principles that govern the mesoscale organisation of chromatin and biomolecular condensates. We investigate how molecular interactions shape their thermodynamics, kinetics, and multiscale architectures. To this end, we develop and apply computational models that bridge all-atom molecular dynamics, coarse-graining techniques, and theoretical approaches, in close collaboration with experimental partners in biochemistry, structural biology, biophysics, and cell biology.

 

Instrinsic Chromatin Phase Separation from Farr et al, Nat Communs (2021)

The Multiscale Structure of a Biomolecular Condensate from Zhou et al. Science (in press) 2025: