For the latest list check our Google Scholar. Last update: October 2025
Preprints (reverse chronogical order)
- Bell C, Chen L, Maristany MJ, Blaukopf C, Perez Lopez JI, Huertas J, Zhou H, Langer CCH, Steinacker TL, Schütte N, Doolittle LK, Espinosa JR, Redding S, Collepardo-Guevara R*, Rosen MK*, Gerlich DW*.
An electrostatic repulsion model of centromere organization
bioRxiv (2025). *Co-corresponding - Pedraza E, Tejedor AR, Feito A, Gómez F, Collepardo-Guevara R, Sanz E, Espinosa JR.
Predicting Saturation Concentrations of Phase-Separating Proteins via Thermodynamic Integration.
bioRxiv (2025). - Espejo NH, Feito A, Sanchez-Burgos I, Garaizar A, Conde MM, Rey A, Castro A, Collepardo-Guevara R, Tejedor AR, Espinosa JR.
Compositional control of ageing kinetics in TDP-43 condensates.
bioRxiv (2025). - Shimazoe MA, Phillips C, Huertas J, Ide S, Tamura S, Farr S, Ashwin SS, Sasai M, Collepardo-Guevara R*, Maeshima K*.
Linker histone H1 functions as a liquid-like glue to organize chromatin in living human cells.
bioRxiv (2025). *Co-corresponding - Tamon L, Fahmi Z, Ashford J, Collepardo-Guevara R, Sahakyan AB.
Analysis of long-range contacts across cell types outlines a core sequence determinant of 3D genome organisation.
bioRxiv (2025). - Sanchez-Burgos I, Tejedor AR, Collepardo-Guevara R, Bernardino de la Serna J, Espinosa JR.
Molecular insight on the mechanism of α1-antitrypsin condensate formation and maturation.
bioRxiv (2025). - Pedraza E, Hoyos D, Feito A, Gámez F, Sanchez-Burgos I, Collepardo-Guevara R, Tejedor AR, Espinosa JR.
Charged mutations in the FUS low-complexity domain modulate condensate ageing kinetics.
bioRxiv (2025). - Sanchez-Burgos I, Tejedor AR, Feito A, Collepardo-Guevara R, Espinosa JR.
Charged peptides enriched in aromatic residues decelerate condensate ageing driven by cross-β-sheet formation.
bioRxiv (2025). - Erkamp NA, Sanchez-Burgos I, Zhou A, Krug TJ, Qamar S, Sneideris T, Zhang E, Nakajima K, Chen A, Collepardo-Guevara R, van Hest J, St George-Hyslop P, Weitz DA, Espinosa JR, Knowles TPJ.
Dynamically arrested condensate fusion creates complex structures with varying material properties.
bioRxiv (2025). - Zhou H, Maristany MJ, Huertas J, Russell K, Hutchings J, Hwang JH, Yao R, Shiozaki M, Zhao X, Doolittle LK, Gibson BA, Espinosa JR, Yu Z, Villa E, Collepardo-Guevara R*, Rosen MK*.
Multi-Scale structure of a biomolecular condensate rationalises phase separation and material properties.
Science (Just Accepted, 2025). *Co-corresponding - Alberti S … Collepardo-Guevara R* et al.
Current practices in the study of biomolecular condensates: a community comment.
Nature Communications (2025). *Co-corresponding - Hangpeg Li et al.
Base pair resolution chromosome conformation capture reveals mechanistic insights into the nature of chromatin structure.
Cell (2025). In press. - Nakashima KK, Mihoubi FZ, Saraya J, Russell K, Rahmatova F, Robinson J, Maristany MJ, Huertas J, Rubio-Sanchez R, Collepardo-Guevara R*, O’Flaherty D*, Bonfio C*.
Compositional and functional diversity of minimal primitive coacervates in a nucleic acid-peptide world.
Nature Communications (2025). *Co-corresponding - Chew PY, Collepardo-Guevara R*.
Probing molecular and biophysical mechanisms of RNA and protein phase transitions with simulations and theory.
Current Opinion in Cell Biology (2025). - Montez M, Zhu D, Huertas Martin J, Maristany MJ, Rutjens Bas, Nielsen M, Collepardo-Guevara R, Dean C.
Cold-induced nucleosome dynamics linked to silencing of Arabidopsis FLC.
Nature Communications (2025). - Chen L, Maristany MJ, Farr SE, Gibson B, Doolittle LK, Redding S, Espinosa JR, Huertas J, Collepardo-Guevara R*, Rosen MK*.
Nucleosome Spacing Can Fine-Tune Higher Order Chromatin Assembly.
Nature Communications (2025). *Co-corresponding - Amaro R, …, Collepardo-Guevara R et al.
The need to implement FAIR principles in biomolecular simulations.
Nature Methods (2025). - Ng TLC, Hoare MP, Maristany MJ, … Collepardo-Guevara R, Kumita J.
Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates.
Chemical Science (2025). - Tejedor AR, Aguirre Gonzalez A, Maristany MJ, Chew PY, Rusell K, Ramirez J, Espinosa JR, Collepardo-Guevara R.
Chemically-informed coarse-graining of electrostatic forces in charge-rich biomolecular condensates.
ACS Central Science (2025). - Feito A, Sanchez-Burgos I, Tejero I, Sanz E, Rey A, Collepardo-Guevara R, Tejedor AR, Espinosa JR.
Benchmarking residue-resolution protein coarse-grained models for simulations of biomolecular condensates.
PLOS Computational Biology (2025). - Maristany MJ, Aguirre Gonzalez A, Espinosa JR, Huertas J, Collepardo-Guevara R, Joseph JA.
Decoding Phase Separation of Prion-Like Domains through Data-Driven Scaling Laws.
eLife (2024). - Feito A, Sanchez-Burgos I, Rey A, Collepardo-Guevara R, Tejedor AR, Espinosa JR.
Capturing single-molecule properties does not ensure accurate prediction of biomolecular phase diagrams.
Molecular Physics (2024). - Torrino S, Oldham W, Tejedor AR, Sanchez-Burgos I, Rachedi N, Fraissard K, Chauvet C, Sbai C, O’Hara BP, Abelanet S, Brau F, Clavel S, Collepardo-Guevara R, Rene Espinosa J, Ben-sahra I, Bertero T.
Mechano-dependent sorbitol accumulation supports biomolecular condensate.
Cell (2024). - Nicy, Joseph JA, Collepardo-Guevara R, Wales DJ.
Energy landscapes and heat capacity signatures for peptides correlate with phase separation propensity.
bioRxiv (2023). - Shen Y, Chen A, Wang W, Shen Y, Ruggeri FS, Aime S, Wang Z, Qamar S, Espinosa JR, Garaizar A, St George-Hyslop P, Collepardo-Guevara R, Weitz DA, Vigolo D, Knowles TPJ.
The liquid-to-solid transition of FUS is promoted by the condensate surface. Proc Natl Acad Sci USA 120:e2301366120 (2023).
https://doi.org/10.1073/pnas.2301366120 - Brown K, Chew PY, Ingersoll S, Espinosa JR, Aguirre A, Kutateladze TG, Collepardo-Guevara R*, Ren X.
Principles of assembly and regulation of condensates of Polycomb repressive complex 1 through phase separation. Cell Reports 42:113136 (2023). *Co-correspondence.
https://doi.org/10.1016/j.celrep.2023.113136 - Chew PY, Joseph JA, Collepardo-Guevara R*, Reinhardt A*.
Aromatic and arginine content drives multiphasic condensation of protein–RNA mixtures. Biophysical Journal 123(11):1342–1355 (2024). *Co-correspondence.
https://doi.org/10.1016/j.bpj.2023.06.024 - Tejedor AR, Collepardo-Guevara R, Ramírez J, Espinosa JR.
Time-Dependent Material Properties of Aging Biomolecular Condensates from Different Viscoelasticity Measurements in Molecular Dynamics Simulations. J Phys Chem B 127:4441–4459 (2023).
https://doi.org/10.1021/acs.jpcb.3c01292 - Blázquez S, Sanchez-Burgos I, Ramírez J, Higginbotham T, Conde MM, Collepardo-Guevara R, Tejedor AR, Espinosa JR.
Location and concentration of aromatic-rich segments dictates the percolating inter-molecular network and viscoelastic properties of ageing condensates. Advanced Science 10:2207742 (2023).
https://doi.org/10.1002/advs.202207742 - Sanchez-Burgos I, Herriott L, Collepardo-Guevara R, Espinosa JR.
Surfactants or scaffolds? RNAs of different lengths exhibit heterogeneous distributions and play diverse roles in RNA–protein condensates. Biophysical Journal 122(7):1295–1307 (2023).
https://doi.org/10.1016/j.bpj.2023.02.021 - Saar K, Qian D, Good L, Morgunov A, Collepardo-Guevara R, Best RB, Knowles TPJ.
Theoretical and data-driven approaches for biomolecular condensates. Chemical Reviews 123(13):7872–7925 (2023).
https://doi.org/10.1021/acs.chemrev.2c00586 - Chew PY, Joseph JA, Collepardo-Guevara R*, Reinhardt A*.
Thermodynamic origins of two-component multiphase condensates of proteins. Chemical Science 14:1820–1836 (2023). *Co-correspondence.
https://doi.org/10.1039/D2SC05873A - Orsborne SRE, Gorman J, Weiss LR, Sridhar A, Panjwani NA, Divitini G, Budden P, Palecek D, Ryan STJ, Rao A, Collepardo-Guevara R, El-Sagheer AH, Brown T, Behrends J, Friend RH, Auras F.
Photogeneration of Spin Quintet Triplet–Triplet Excitations in DNA-Assembled Pentacene Stacks. J Am Chem Soc 145(9):5431–5438 (2023).
https://doi.org/10.1021/jacs.2c13743 - Zhu H+, Narita M+, Joseph JA+, Krainer G, Arter WE, Saar KL, Ermann N, Espinosa JR, Shen Y, Kuri MA, Qi R, Xu Y, Collepardo-Guevara R*, Narita M*, Knowles TPJ*.
The chromatin regulator HMGA1a undergoes phase separation in the nucleus. ChemBioChem 23(23):e202200450 (2022). *Co-correspondence; +co-first authors.
https://doi.org/10.1002/cbic.202200450 - Tejedor AR+, Sanchez-Burgos I+, Estevez-Espinosa M, Garaizar A, Collepardo-Guevara R, Ramírez J, Espinosa JR.
Protein structural transitions critically transform the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it. Nature Communications 13:5713 (2022). +co-first authors.
https://doi.org/10.1038/s41467-022-32874-0 - Garaizar A, Espinosa JR, Joseph JA, Krainer G, Shen Y, Knowles TPJ, Collepardo-Guevara R.
Aging can transform single-component protein condensates into multiphase architectures. Proc Natl Acad Sci USA 119:e2119800119 (2022).
https://doi.org/10.1073/pnas.2119800119 - Huertas J, Woods EJ, Collepardo-Guevara R.
Multiscale modelling of chromatin organisation: Resolving nucleosomes at near-atomistic resolution inside genes. Curr Opin Cell Biol 75:102067 (2022).
https://doi.org/10.1016/j.ceb.2022.102067 - Garaizar A, Espinosa JR, Joseph JA, Collepardo-Guevara R.
Kinetic interplay between droplet maturation and coalescence modulates shape of aged protein condensates. Scientific Reports 12:4390 (2022).
https://doi.org/10.1038/s41598-022-08130-2 - Sanchez-Burgos I, Espinosa JR, Joseph JA, Collepardo-Guevara R.
RNA length has a non-trivial effect in the stability of biomolecular condensates formed by RNA-binding proteins. PLOS Computational Biology 18(2):e1009810 (2022).
https://doi.org/10.1371/journal.pcbi.1009810 - Welsh TJ+, Krainer G+, Espinosa JR+, Joseph JA, Sridhar A, Collepardo-Guevara R*, Alberti S*, Knowles TPJ*.
Surface Electrostatics Govern the Emulsion Stability of Biomolecular Condensates. Nano Letters 22(2):612–621 (2022). *Co-correspondence; +co-first authors.
https://doi.org/10.1021/acs.nanolett.1c03138 - Gorman J, Orsborne SRE, Sridhar A, Pandya R, Budden P, Ohmann A, Panjwani NA, Liu Y, Greenfield JL, Dowland S, Gray V, Ryan STJ, De Ornellas S, El-Sagheer AH, Brown T, Nitschke JR, Behrends J, Keyser UF, Rao A, Collepardo-Guevara R, Stulz E, Friend RH, Auras F.
Deoxyribonucleic Acid Encoded and Size-Defined π-Stacking of Perylene Diimides. J Am Chem Soc 144(1):368–376 (2022).
https://doi.org/10.1021/jacs.1c10241 - Joseph JA, Reinhardt A, Aguirre A, Chew PY, Russell K, Espinosa JR, Garaizar A, Collepardo-Guevara R.
Physics-driven coarse-grained model for biomolecular phase separation with near-quantitative accuracy. Nature Computational Science 1(11):732–743 (2021).
https://doi.org/10.1038/s43588-021-00155-3 - Itoh Y, Woods EJ, Minami K, Maeshima K, Collepardo-Guevara R.
Local chromatin structure and dynamics: What can we learn from imaging and computational modeling?
Current Opinion in Structural Biology 71:123–135 (2021).
https://doi.org/10.1016/j.sbi.2021.05.004 - Da Rosa G, Perez A, Orozco M, Collepardo-Guevara R et al.
Sequence-dependent structural properties of B-DNA: what have we learned in 40 years?
Biophysical Reviews 13:597–610 (2021).
https://doi.org/10.1007/s12551-021-00799-6 - Lichtinger SM, Garaizar A, Collepardo-Guevara R*, Reinhardt A*.
Targeted modulation of protein liquid–liquid phase separation by evolution of amino acid sequence.
PLOS Computational Biology 17(8):e1009328 (2021). *Co-correspondence.
https://doi.org/10.1371/journal.pcbi.1009328 - Sanchez-Burgos I, Joseph JA, Collepardo-Guevara R, Espinosa JR.
Size conservation emerges spontaneously in biomolecular condensates formed by scaffolds and surfactant clients.
Scientific Reports 11:15241 (2021).
https://doi.org/10.1038/s41598-021-94746-2 - Farr SE, Woods EJ, Joseph JA, Garaizar A, Collepardo-Guevara R.
Nucleosome plasticity is a critical element of chromatin liquid–liquid phase separation and multivalent nucleosome interactions.
Nature Communications 12:2883 (2021).
https://doi.org/10.1038/s41467-021-23186-8 - Joseph JA, Espinosa JR, Sanchez-Burgos I, Garaizar A, Frenkel D, Collepardo-Guevara R.
Thermodynamics and kinetics of phase separation of protein–RNA mixtures by a minimal model.
Biophysical Journal 120(7):1219–1230 (2021).
https://doi.org/10.1016/j.bpj.2021.02.017 - Krainer G+, Welsh TJ+, Joseph JA+, Espinosa JR, Wittmann S, de Csilléry E, Sridhar A, Toprakcioglu Z, Gudiskyte G, Czekalska MA, Arter WE, Guillén-Boixet J, Franzmann TM, St George-Hyslop P, Hyman AA*, Collepardo-Guevara R*, Alberti S*, Knowles TPJ*.
Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and nonionic interactions.
Nature Communications 12:1085 (2021). *Co-correspondence; +co-first authors.
https://doi.org/10.1038/s41467-020-20663-z - Sanchez-Burgos I, Espinosa JR, Joseph JA, Collepardo-Guevara R.
Valency and binding affinity variations can regulate the multilayered organization of protein condensates with many components.
Biomolecules 11(2):278 (2021).
https://doi.org/10.3390/biom11020278 - Garaizar A, Sanchez-Burgos I, Collepardo-Guevara R, Espinosa JR.
Expansion of intrinsically disordered proteins increases the range of stability of liquid–liquid phase separation.
Molecules 25(20):4705 (2020).
https://doi.org/10.3390/molecules25204705 - Espinosa JR, Joseph JA, Garaizar A, Sanchez-Burgos I, Frenkel D, Collepardo-Guevara R.
Liquid network connectivity regulates the stability and composition of biomolecular condensates with many components.
Proc Natl Acad Sci USA 117(24):13238–13247 (2020).
https://doi.org/10.1073/pnas.2001999117 - Sridhar A, Farr SE, Portella G, Schlick T, Orozco M, Collepardo-Guevara R.
Emergence of chromatin hierarchical loops from protein disorder and nucleosome asymmetry.
Proc Natl Acad Sci USA 117(13):7216–7224 (2020).
https://doi.org/10.1073/pnas.1912327117 - Sridhar A, Orozco M, Collepardo-Guevara R.
Protein disorder-to-order transition enhances the nucleosome binding affinity of H1.
Nucleic Acids Research 48(10):5318–5331 (2020).
https://doi.org/10.1093/nar/gkaa254 - Sandoval-Perez A, Garaizar A, Farr SE, Berger R, Brehm MA, König G, Schneider SW, Huck V, Rädler JO, Collepardo-Guevara R, Aponte-Santamaría C.
DNA binds to a specific site of the adhesive blood-protein von Willebrand factor guided by electrostatic interactions.
Nucleic Acids Research 48(12):6839–6851 (2020).
https://doi.org/10.1093/nar/gkaa466 - Espinosa JR, Garaizar A, Vega C, Frenkel D, Collepardo-Guevara R.
Breakdown of the law of rectilinear diameter and related surprises in the liquid–vapor coexistence in systems of patchy particles.
J Chem Phys 150(22):224510 (2019).
https://doi.org/10.1063/1.5093793 - Collepardo-Guevara R, Portella G, Frenkel D, Vendruscolo M, Schlick T, Orozco M.
Chromatin unfolding by epigenetic modifications explained by dramatic impairment of internucleosome interactions: A multiscale computational study.
J Am Chem Soc 137:10205–10215 (2015).
https://doi.org/10.1021/jacs.5b03448 - Gungor O, Collepardo-Guevara R, Schlick T.
Forced unravelling of chromatin fibers with nonuniform linker DNA lengths.
J Phys: Condens Matter 27:064113 (2015).
https://doi.org/10.1088/0953-8984/27/6/064113 - Collepardo-Guevara R, Schlick T.
Chromatin fiber polymorphism triggered by variations of DNA linker lengths.
Proc Natl Acad Sci USA 111:8061–8066 (2014).
https://doi.org/10.1073/pnas.1315872111 - Chakraborty D, Collepardo-Guevara R, Wales DJ.
Energy landscapes, folding mechanisms, and kinetics of RNA tetraloop hairpins.
J Am Chem Soc 136:18052–18061 (2014).
https://doi.org/10.1021/ja507502e - Arcella A, Portella G, Collepardo-Guevara R, Chakraborty D, Wales DJ, Orozco M.
Structure and properties of DNA in apolar solvents.
J Phys Chem B 118:8540–8548 (2014).
https://doi.org/10.1021/jp502453d - Luque A, Collepardo-Guevara R, Grigoryev S, Schlick T.
Dynamic condensation of linker histone C-terminal domain regulates chromatin structure.
Nucleic Acids Research 42:7553–7560 (2014).
https://doi.org/10.1093/nar/gku449 - Hospital A, Faustino I, Collepardo-Guevara R, González C, Lluís Gelpí J, Orozco M.
NAFlex: A web server for the study of nucleic acids flexibility.
Nucleic Acids Research 41:W47–W55 (2013).
https://doi.org/10.1093/nar/gkt385 - Collepardo-Guevara R, Schlick T.
Insights into chromatin fibre structure by in vitro and in silico single-molecule stretching experiments.
Biochem Soc Trans 41:494–500 (2013).
https://doi.org/10.1042/BST20120161 - Collepardo-Guevara R, Schlick T.
Crucial role of dynamic linker histone binding for DNA accessibility and gene regulation revealed by mesoscale modeling of oligonucleosomes.
Nucleic Acids Research 40:8803–8817 (2012).
https://doi.org/10.1093/nar/gks617 - Collepardo-Guevara R, Schlick T.
The effect of linker histone’s nucleosome binding affinity on chromatin unfolding mechanisms.
Biophysical Journal 101:1670–1680 (2011).
https://doi.org/10.1016/j.bpj.2011.07.056 - Schlick T, Collepardo-Guevara R.
Biomolecular Modeling and Simulation: The Productive Trajectory of a Field.
SIAM News 44:6 (2011).
https://archive.siam.org/news/news.php?id=1905 - Schlick T, Collepardo-Guevara R, Halvorsen LA, Jung S, Xiao X.
Biomolecular modelling and simulation: a field coming of age.
Quarterly Reviews of Biophysics 43:159–190 (2010/2011).
https://doi.org/10.1017/S0033583510000116 - Perisic O+, Collepardo-Guevara R+, Schlick T.
Modelling studies of chromatin fiber structure as a function of DNA linker length.
J Mol Biol 403:777–802 (2010). +co-first author.
https://doi.org/10.1016/j.jmb.2010.09.001 - Suleimanov Y, Collepardo-Guevara R, Manolopoulos DE.
Bimolecular reaction rates from ring polymer molecular dynamics: application to H + CH₄ → H₂ + CH₃.
J Chem Phys 134:044131 (2011).
https://doi.org/10.1063/1.3518362 - Collepardo-Guevara R, Suleimanov Y, Manolopoulos DE.
Bimolecular chemical reaction rates from ring polymer rate theory.
J Chem Phys 130:174713 (2009).
https://doi.org/10.1063/1.3125436 - Collepardo-Guevara R, Craig IR, Manolopoulos DE.
Proton transfer in a polar solvent from ring polymer molecular dynamics reaction rate theory.
J Chem Phys 128:144502 (2008).
https://doi.org/10.1063/1.2895754 - Collepardo-Guevara R, Corvera Poiré E.
Controlling viscoelastic flow by tuning frequency during occlusions.
Phys Rev E 76:026301 (2007).
https://doi.org/10.1103/PhysRevE.76.026301 - Collepardo-Guevara R, Corvera Poiré E.
Maximizing the dynamic permeability during occlusions.
Eur Phys J Special Topics 143:95–101 (2007).
https://doi.org/10.1140/epjst/e2007-00058-y - Collepardo-Guevara R, Walter D, Neuhauser D, Baer R.
A Hückel study of the effect of a molecular cavity on the quantum conductance of an alkene wire.
Chem Phys Lett 393:367–372 (2004).
https://doi.org/10.1016/j.cplett.2004.06.114